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The goal of neuroi- maging is the identification of intracranial hemorrhage buy generic zestoretic 17.5mg line, focal or distributed parench- ymal injury discount 17.5 mg zestoretic free shipping, or structural developmental abnormalities discount zestoretic 17.5mg overnight delivery. Cranial ultrasound can be performed at the bedside and is effective in identifying intraventricular and many parenchymal hemorrhages buy cheap zestoretic 17.5 mg line, but has limitations in its ability to detect focal infarcts order zestoretic 17.5mg otc, developmental abnormalities, and convexity hemorrhages. CT or MRI yields more information but usually require skilled transportation from the neonatal intensive care unit to the radiology suite, and may need to be deferred, at least initially, until the infant is stabilized. THERAPY Treatment of the newborn with seizures involves general supportive measures, management of any underlying disorder, and often requires treatment with anticonvulsant medication. Seizures themselves and treatment with anticonvulsant medication may impair respiratory drive and the ability to maintain adequate circulation. Therefore, supportive management to ensure maintenance of adequate ventilation and perfusion is imperative. Further discussion of this important area is beyond the scope of this chapter, and the reader is referred to other sources on general neonatal medical management. Apart from recommendations for acute Neonatal Seizures 63 Table 1 Neonatal Seizures: Etiologies to Consider Vascular and perfusion abnormalities Hypoxic–ischemic injury Stroke Sinovenous thrombosis Intracranial hemorrhage Intraventricular Parenchymal Subdural Subarachnoid CNS infection Malformations and other structural lesions Neuronal migration disorders Cerebral dysgenesis Neurocutaneous disorders, e. The decision to treat neonatal seizures with anticonvulsant drugs depends on the risk of acute seizure-related respiratory or cardiac decompensation in a critically ill newborn, as well as the potential for long-term seizure-related neurological injury balanced against the potential adverse effects of anticonvulsant medications. Some newborns may not need treatment with anticonvulsant medication, for instance, those with seizures due to reversible and appropriately treated metabolic derange- ments, or those with rare, short-lived events. However, in considering a decision not to treat, it is important to recognize that a significant proportion of newborns with electroclinical seizures have additional clinically silent electrographic seizures. Table 2 Initial Management of Acute Metabolic Disorders Hypoglycemia 10–15% dextrose, 2–3 mL=kg IV Hypocalcemia 5% calcium gluconate, 2 mL=kg IV Hypomagnesemia 2–3% magnesium sulfate, 2 mg=kg IV 64 Bergin This is particularly likely in premature infants and those with severe encephalopathy. Prolonged EEG monitoring is helpful in identifying the presence of unsuspected elec- trographic seizures. The importance of these subclinical events in the genesis of sei- zure-related neuronal injury is unknown at present. In the setting of severe neonatal encephalopathy, these events may be prolonged and refractory to treatment, and efforts to eliminate them may be limited by systemic vulnerability to the circulatory effects of anticonvulsant medications. A number of factors alter the pharmacokinetics of the anticonvulsant drugs in neonates. Physiological immaturity delays drug elimination, and asphyxial injury to the liver and kidney may further delay metabolism. Maturation of the various path- ways involved in drug metabolism occurs at variable rates over the first weeks of life, and recovery from perinatal injury improves hepatic and renal function. Overall, there is a dramatic increase in the ability to eliminate the commonly used anticonvul- sant drugs, so that changes in dosing are required to maintain therapeutic drug levels over the first weeks of life. When anticonvulsant treatment is indicated, phenobarbital is the drug most commonly used as first-line therapy. Other first-line options include benzodiazepines (diazepam, lorazepam), and phenytoin or, if available, its prodrug fosphenytoin. There have been few studies comparing the efficacy of these drugs in the treatment of neonatal seizures. Typical initial doses of the first-line drugs are provided in Table 3, and additional discussion of the individual drugs is given below. Phenobarbital: Phenobarbital affects GABAA receptors to enhance GABA- related inhibition. It may also inhibit excitatory amino acid transmission and block voltage-activated calcium currents. Phenobarbital is subject to protein binding, and it is the unbound (free), unionized fraction that is active. Alterations in acid–base balance in the newborn may impact efficacy of the drug for this reason. Its half-life is long, from 100 to 300 hr, or longer in prema- ture infants, but declines to 100 hr or less over the first weeks of life. An initial intra- venous (IV) loading dose of 20 mg=kg may be followed by increments of 5–10 g=kg IV to a total of 40 g=kg, with higher doses associated with improved efficacy. Careful monitoring of cardiac and respiratory function may be required in vulnerable infants. Table 3 Anticonvulsant Drug Doses for Initial Management of Neonatal Seizures Drug Initial dose Maintenance Phenobarbital 20 mg=kg IV. Consider further Check drug levels—may not need 5–10 mg=kg increments to a further doses for many days.

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However buy discount zestoretic 17.5 mg on-line, once this has been done the analysis is quick and efficient purchase 17.5 mg zestoretic free shipping, with most software packages producing well presented graphs generic zestoretic 17.5 mg without prescription, pie charts and tables which can be used for the final report buy zestoretic 17.5mg on-line. QUALITATIVE DATA ANALYSIS To help you with the analysis of qualitative data purchase 17.5 mg zestoretic fast delivery, it is use- ful to produce an interview summary form or a focus group summary form which you complete as soon as possible after each interview or focus group has taken place. This includes practical details about the time and place, the participants, the duration of the interview or focus group, and details about the content and emerging themes (see Figures 2 and 3). It is useful to complete these forms as 112 / PRACTICAL RESEARCH METHODS soon as possible after the interview and attach them to your transcripts. The forms help to remind you about the contact and are useful when you come to analyse the data. The method you use will depend on your research topic, your personal preferences and the time, equipment and fi- nances available to you. Also, qualitative data analysis is a very personal process, with few rigid rules and procedures. It is for this reason that each type of analysis is best illu- strated through examples (see Examples 8–11 below). Formats for analysis However, to be able to analyse your data you must first of all produce it in a format that can be easily analysed. This might be a transcript from an interview or focus group, a series of written answers on an open-ended questionnaire, or field notes or memos written by the researcher. It is useful to write memos and notes as soon as you begin to collect data as these help to focus your mind and alert you to significant points which may be coming from the data. These memos and notes can be analysed along with your transcripts or questionnaires. You can think of the different types of qualitative data analysis as positioned on a continuum (see Fig. HOW TO ANALYSE YOUR DATA/ 113 Interviewee: ________________ D at e o f I n t erview:________________ P l ac e : ________________________ Time of Interview:________________ Duration of Interview: __________ Where did the interview take place? Did any issues arise which need to be added to the interview schedule for next time? Have I promised to send any information or supply them with the results or a copy of the transcript? Interview summary form 114 / PRACTICAL RESEARCH METHODS D at e : ________________________ Time:_________________________________ Ve n u e : ______________________ D u r at ion: ___________________________ G rou p : ______________________ Diagram of seating plan with participant codes: Where did the focus group take place? Does anything need to be added to the in- terview schedule for the next focus group? Have I promised to send any further informa- tion or the final report to anyone? Qualititative data analysis continuum For those at the highly qualitative end of the continuum, data analysis tends to be an on-going process, taking place throughout the data collection process. The researcher thinks about and reflects upon the emerging themes, adapt- ing and changing the methods if required. For example, a researcher might conduct three interviews using an inter- view schedule she has developed beforehand. However, during the three interviews she finds that the participants are raising issues that she has not thought about pre- viously. So she refines her interview schedule to include these issues for the next few interviews. She has thought about what has been said, analysed the words and refined her schedule accordingly. Thematic analysis When data is analysed by theme, it is called thematic ana- lysis. This type of analysis is highly inductive, that is, the themes emerge from the data and are not imposed upon it by the researcher. In this type of analysis, the data collec- 116 / PRACTICAL RESEARCH METHODS tion and analysis take place simultaneously. Even back- ground reading can form part of the analysis process, especially if it can help to explain an emerging theme. EXAMPLE 8: RICHARD Richard was interested in finding out what members of the public thought about higher education.

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She was able to get herself dressed and undressed and—“ “I was able to get dressed and undressed by myself before that buy cheap zestoretic 17.5mg online,” Esther interrupted generic 17.5 mg zestoretic free shipping. One day during my surgical rotation in medical school zestoretic 17.5 mg with mastercard, my right leg suddenly collapsed buy zestoretic 17.5mg on line, and the fall broke a small bone in my foot—the fifth metatarsal buy 17.5mg zestoretic fast delivery. It precipitated a barrage of eerily identical questions:“Did you have a skiing accident? Taking the rope tow up the beginner slope, unsteady on rented skis, I felt an unpleasant choking sensation. The twisting rope tow had somehow latched onto the fringe of the scarf peeking out below my parka. After they stopped the tow and unwound me, I sat out the rest of the day. Somehow social convention demands a more complete explanation, but my MS was private. If I, a medical student, men- tioned my MS, I reasoned, patients may lose faith in me or think I’m seek- ing sympathy. Bur- dening them with my disease, even by explaining my cane, seemed presumptuous. When propped in a corner, it in- variably fell, with a clatter, to the tile floor. If placed on the floor in cramped hospital rooms, someone, including me, could trip over it. Girded by these rationalizations, I began stashing—hiding—the cane at the nurse’s station or utility room before entering patients’ rooms, carefully clutching the doorjamb. Unlike Fred Astaire’s glossy, svelte walking stick, real mobility aids clearly aim to 181 182 mbulation Aids support or transport persons. These aids generally do their jobs well, eas- ing pain, enhancing balance, maximizing safety, helping people get around. Mobility aids can restore independence and conserve energy drained by enervating struggles to walk. Users of mobility aids openly admit—both to themselves and the exter- nal world—their lost physical function and consequent need. After in- juries, walking short-term with canes or crutches evokes sympathetic in- quiries about that presumed skiing or other accident. When I fractured my foot and adopted the cane, surgeons regaled me with stories of their own broken bones (but never asked about my injury). Long-term, however, mo- bility aids carry not only weight, quite literally, but also a hefty symbol- ism. One study found that about half of people with great difficulty walking one-quarter mile do not use any assistance; they probably simply avoid walking that far (Ver- brugge, Rennert, and Madans 1997, 386). Using equipment to aid mobility, however, enhances people’s sense of autonomy and self-sufficiency. With increasing technological sophistication, mobility aids can offer efficient al- ternatives to costly personal assistance and institutionalization, even for people with significant physical limitations. Chapters 11 and 12 explore the contradictions surrounding mobility aids, juxtaposing their important advantages with persisting individual and societal unease. Chapter 11 considers ambulation aids (canes, crutches, walkers) but not potentially useful items fabricated for particular needs (special shoes, splints, braces, orthotics, or limb prostheses). As a bottom line, decisions about mobility aids and all assistive tech- nologies (AT) must reflect the user’s needs, circumstances, and preferences. AT choice should include the right to choose or to reject AT” (Olkin 1999, 291). Almost inevitably, others weigh in—family members, physicians, physical and occupational therapists,AT vendors, and health insurers. Decisions about mobility aids can become complicated and emotionally charged. Use of Mobility Aids by People with Major Mobility Difficulties Mobility Aid (%) Difficulty Cane Walker Wheelchair Arthritis 44 26 16 Back problems and sciatica 34 10 5 Heart conditions 30 15 14 Lung conditions 16 11 12 Stroke 48 28 44 Missing lower limb 57 30 23 Diabetes 37 40 35 Multiple sclerosis 36 29 66 million) use canes; 0. After accounting for various personal factors,4 we find that cane users live alone 50 percent more frequently than other people, and walker users 30 percent more often. The survey has no information on whether mobility aids allow people to live alone more independently and safely than without the equipment. Mobility aids have their own hierarchy, from low-tech wooden canes with crook handles, to multifooted canes, to crutches, to walkers, to manual wheelchairs and scooters, to sophisticated power wheelchairs.

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It is a general observation that hips with a small labral avulsion normally become asymptomatic even without an attempt to resect or refix this structure buy 17.5 mg zestoretic otc. It may be possible with smaller rim fragments that become unloaded in a similar way after osteotomy and may eventually consolidate zestoretic 17.5mg free shipping. Intraosseous ganglia also can disappear spontaneously after a redirection of the acetabulum purchase 17.5mg zestoretic free shipping. However best 17.5 mg zestoretic, as soon as these lesions surpass a certain size purchase zestoretic 17.5mg, an attempt to treat the lesion is justified or even recommended. This conclusion is especially true for large and floating bucket-handle lesions of a degenerated labrum (Fig. We further learned over the years that acetabular dysplasia is not uniform antero- lateral insufficiency of coverage of the femoral head but shows a multitude of pure and combined anterior, lateral, and posterior dysplasias. Li and Ganz showed that one of six dysplastic hips were retroverted (Fig. Although the classic anterolateral dysplasia remains the most common, pure lateral deficiency of coverage is rare and the pure posterior deficiency is an exception, and then is seen in functional hips of proximal Fig. Intraoperative view of a bucket-handle avulsion of a degenerated labrum (arrow) Fig. AP-pelvic radiograph of the dysplastic acetabulum of an Asian woman shows retroversion of the superior one-third of the acetabulum 154 R. Leunig femoral focal deficiency (PFFD) or posttraumatic dysplasia. One important group of a posterior insufficiency of coverage or anterior overcoverage consists of hips with Salter or triple osteotomies in childhood in which a correct version of the acetabulum was difficult to establish in the presence of an unossified acetabular rim. If a retroverted dysplastic acetabulum is redirected in the same way as an antero- laterally dysplastic acetabulum, the problem of this hip may be increased and further treatment even more difficult. The acetabulum is extremely retroverted (arrows show the anterior border; the posterior border is hidden behind the inner acetabular wall). On the femoral side the head is deformed, the neck is short, and there is subtrochanteric abduction with medialization of the femoral shaft. The hip showed impingement with 40° flexion, creating severe problems with sitting on a chair. To bridge the displacement necessary for such a correction, the plate had to be prebended stepwise. Fixation was then only possible on the inside of the stable ilium and on the outside of the acetabular fragment. On the femoral side, femoral neck lengthening, trochanteric advancement, and subtrochanteric alignment were necessary to regain an anatomical morphology Periacetabular Osteotomy in Treatment of Hip Dysplasia 155 Our first 75 cases with a minimum of 10 years’ follow-up (10–13. Taking all hips, the success rate dropped to 73% with good or excellent results. The higher early failure rate was in the group with grade III osteoarthritis, an observation that caused us to exclude most of such hips from the indication for a reorientation. A standard AP X-ray, however, may be misleading when the joint space narrowing is rather the result of an anterolateral subluxation and does not represent cartilage loss. Such hips can be an acceptable indication and may lead to a good result for years, helping to postpone an artificial joint for a prosthesis lifetime (Fig. Very early failures were observed also in reoriented hips with a secondary acetabulum. With our 10-year follow-up study we had unexpectedly found that 30% of the patients had developed impingement symptoms over the years. These symptoms were in most of the patients not severe enough, very severe, or only detectable with the impingement test, but in this small group hips were included with perfect corrections of the acetabulum. Further studies showed that the anterolateral head– neck junction in dysplastic hips frequently had no waist, producing a decreased clearance for flexion/internal rotation after correction of the acetabular roof. The patient has now problems with the left hip and is ready for total hip replacement (THR) 156 R. Continued c d e Periacetabular Osteotomy in Treatment of Hip Dysplasia 157 As an intraoperative consequence we check routinely this motion and perform an anterolateral osteochondroplasty of the head–neck junction in seven of ten hips to improve the offset (Fig. The necessary capsulotomy allows further treatment of any additional intraarticular pathology, which surprisingly often escapes preopera- tive evaluation. So far, the clinical follow-up of our more recent cases seems to support this additional treatment step. Retroversion of the acetabulum is not only a phenomenon in residual acetabular dysplasia but is common in nondysplastic hips as well; some of these idiopathic ret- roversions have a substantial degree. Such hips become symptomatic in early adult- hood as a result of impingement of the anterior overcoverage against the head–neck a b Fig.

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